Varnat, F., Zacchetti, G. and Ruiz i Altaba, A. (2009). Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling. Mechanisms of Development. In press.

Varnat, F., Duquet, A., Malerba, M., Zbinden, M., Mas, C., Gervaz, P. and Ruiz i Altaba, A. (2009) HEDGEHOG-GLI signaling is active in human epithelial tumor cells and is essential for colon cancer growth, recurrence, metastases and stem cell expansion. EMBO Molecular Medicine 1: 338-351.

Stecca, B. and Ruiz i Altaba, A. (2009). A GLI1-p53 inhibitory loop regulates neural stem and tumor cell numbers. EMBO J. 28, 663-676.

Arianna De Toni , Marie Zbinden, Jonathan A Epstein , Ariel Ruiz i Altaba, Alain Prochiantz and Isabell Caille (2008) Regulation of survival in adult hippocampal stem cell lineages by the homeodomain-only protein HOP. Neural Development 132:3267-3279.

Clement, V., Sanchez, P., De Tribolet, N., Radovanovic, I. and Ruiz i Altaba, A. (2007). Hedgehog-GLI signaling regulates human glioma growth, cancer stem cell self-renewal and tumorigenicity. Current Biology 17, 165-172.

Stecca, B., Mas, C., Clement, V., Zbinden, M., Correa, R., Piguet, V., Beermann, F. and Ruiz i Altaba (2007). Melanomas require Hedgehog-Gli signaling regulated by interactions between GLI1 an the RAS-MEK/AKT pathways. Proc. Natl. Acad. Sci. USA 104, 5895-5900.

Nguyen, V., Chokas, A.L., Stecca, B., Ruiz i Altaba. A. (2005) Cooperative requirement of the Gli proteins in neurogenesis. Development 132:3267-3279 .

Palma, V., Lim, D., Dahmane, Sanchez, P., Brionne, T.C, Herzberg, C.D., Gttton, Y., Carleton, A., Alvarez-Buylla, A. and Ruiz i Altaba, A. (2005) Shh-Gli signaling controls stem cell behavior in the postnatal and adult brain. Development 132, 335-344.

Sanchez P, Ruiz i Altaba A. (2005) In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice. Mechanisms of Development 122, 223-230.

Sanchez P, Hernandez AM, Stecca B, Kahler AJ, DeGueme AM, Barrett A, Beyna M, Datta MW, Datta S, Ruiz i Altaba A. (2004) Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc. Natl. Acad. Sci USA 101:12561-12566.

Palma, and Ruiz i Altaba, A. (2004) Hedgehog-Gli signaling controls the behavior of cells with stem cell properties in the developing neocortex. Development 131, 337-345.

Erich Roessler, Yangzu Du, Jose L. Mullor, Esther Casas, William P. Allen, Ian Ellis, Gabriele Gillessen-Kaesbach, Elizabeth R. Roeder, Jeffrey E. Ming, Ariel Ruiz i Altaba, Maximilian Muenke (2003) Loss-of-function mutations in the human GLI2 gene cause holoprosencephaly and familial pan-hypopituitarism. Proc. Natl. Acad. Sci. USA 100, 13424-13429.

Gitton, Y., Dahmane, N., Baik, S., Ruiz i Altaba, A. Neidhardt, L., Scholze, M., Herrmann, B., Kahlem, P., Kahla A., Schrinner, S., Yildirimman, R., Herwig, R., Lehrach, H. and Yaspo, M.L. (2002) A multi-level gene expression analysis of human chromosome 21 orthologs in the mouse: potential insights into Down syndrome. Nature 420, 586-590.

Dahmane, N., Sanchez, P., Gitton, Y., Palma, V., Sun, T., Weiner, H. and Ruiz i Altaba, A. (2001) The SHH-Gli pathway in brain growth and tumorigenesis. Development 128:5201-5212.

Mullor, J.L., Dahmane, N., Sun, T. and Ruiz i Altaba, A. (2001) Wnt signals are targets and mediators of Gli function. Current Biology 11, 769-773.

Brewster, R. and Ruiz i Altaba, A. (2000). Hexokinase I is a Gli2-responsive gene expressed in the embryonic CNS. Mech. Dev. 99, 159-162

Brewster, R., Mullor, J. and Ruiz i Altaba, A. (2000). Gli2 functions in FGF signaling during antero-posterior paterning. Development 127, 4395-4405.

Aza-Blanc, P., Lin, H-Y., Ruiz i Altaba, A. and Kornberg, T. (2000). Expression of vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities. Development 127, 4293-4301.

Ruiz i Altaba, A. (1999). Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 126,3205-3216.

Dahmane, N. and Ruiz i Altaba, A. (1999). Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 126, 3089-3100.

Ruiz i Altaba, A. (1998). Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 125, 2203-2212.

Liu, F., Massagué, J. & Ruiz i Altaba, A. (1998). Carboxy-terminally truncated Gli3 proteins associated with Smads. Nature Genetics 20:325-326.

Brewster, R., Lee, J. and Ruiz i Altaba, A. (1998) Gli/Zic factors pattern the neural plate by defining domains of cell differentiation. Nature 393, 579-583.

Nothias, F., Fishell, G. and Ruiz i Altaba, A. (1998) Cooperation of intrinsic and extrinsic signals in the determination of regional identity of the posterior neocortex. Curr. Biol. 8, 459-462

Dahmane, N., Lee, J., Robins, P., Heller, P. and Ruiz i Altaba, A. (1997) Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature 389:876-881.

Lee, J., Platt, K., Censullo, P. and Ruiz i Altaba, A. (1997) Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 124:2537-2552.

Ruiz i Altaba, A. and Théry, C. (1996) Involvement of Livertine, a hepatocyte growth factor family member, in neural morphogenesis. Mech. Dev. 60:207-220.

Ruiz i Altaba, A. (1996) Coexpression of HNF-3b and Isl-1/2 and mixed distribution of ventral cell types in the early neural tube. Int. J. Dev. Biol. 40:1081-1088.

Ruiz i Altaba, A., Roelink, H. and Jessell, T.M. (1995) Restrictions to Floor Plate Induction by hedgehog and Winged Helix Genes in the Neural Tube of Frog Embryos. Mol. Cell. Neurosci. 6:106-121.

Ruiz i Altaba, A. Placzek, M., Baldassare, M. Dodd, J. and Jessell, T.M. (1995) Early Stages of Notochord and Floor Plate Differentiation Defined by Normal and Induced Expression of HNF-3b in Chick Embryos. Dev. Biol. 170:299-313.