• Zbinden, M., Duquet, A., Lorente-Trigos, A., Ngwabyt, S.N., Borges, I., Ruiz i Altaba, A. (2010) NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53. /EMBO J/. [Epub ahead of print].
  • Varnat, F., Zacchetti, G., Ruiz i Altaba, A. (2009) Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling. /Mech Dev/. 127, 73-81.
  • Varnat, F., Duquet, A., Malerba, M., Zbinden, M., Mas, C., Gervaz, P. and Ruiz i Altaba, A. (2009) HEDGEHOG-GLI signaling is active in human epithelial tumor cells and is essential for colon cancer growth, recurrence, metastases and stem cell expansion. EMBO Molecular Medicine 1: 338-351.
  • Stecca, B. and Ruiz i Altaba, A. (2009). A GLI1-p53 inhibitory loop regulates neural stem and tumor cell numbers. EMBO J. 28, 663-676.
  • Arianna De Toni , Marie Zbinden, Jonathan A Epstein , Ariel Ruiz i Altaba, Alain Prochiantz and Isabell Caille (2008) Regulation of survival in adult hippocampal stem cell lineages by the homeodomain-only protein HOP. Neural Development 132:3267-3279.
  • Clement, V., Sanchez, P., De Tribolet, N., Radovanovic, I. and Ruiz i Altaba, A. (2007). Hedgehog-GLI signaling regulates human glioma growth, cancer stem cell self-renewal and tumorigenicity. Current Biology 17, 165-172.
  • Stecca, B., Mas, C., Clement, V., Zbinden, M., Correa, R., Piguet, V., Beermann, F. and Ruiz i Altaba (2007). Melanomas require Hedgehog-Gli signaling regulated by interactions between GLI1 an the RAS-MEK/AKT pathways. Proc. Natl. Acad. Sci. USA 104, 5895-5900.
  • Nguyen, V., Chokas, A.L., Stecca, B., Ruiz i Altaba. A. (2005) Cooperative requirement of the Gli proteins in neurogenesis. Development 132:3267-3279 .
  • Palma, V., Lim, D., Dahmane, Sanchez, P., Brionne, T.C, Herzberg, C.D., Gttton, Y., Carleton, A., Alvarez-Buylla, A. and Ruiz i Altaba, A. (2005) Shh-Gli signaling controls stem cell behavior in the postnatal and adult brain. Development 132, 335-344.
  • Sanchez P, Ruiz i Altaba A. (2005) In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice. Mechanisms of Development 122, 223-230.
  • Lorente-Trigos A, Varnat F, Melotti A, and Ruiz i Altaba A. (2010) BMP signaling promotes the growth of primary human colon carcinomas in vivo. J Mol Cell Biol. 2, 318-32
  • Varnat F, Duquet A, Malerba M, Zbinden M, Mas C, Gervaz P, Ruiz i Altaba A.
    Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion.
    EMBO Mol Med. 2009 Sep;1(6-7):338-51.
  • Varnat F, Siegl-Cachedenier I, Malerba M, Gervaz P, Ruiz i Altaba A. Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas. EMBO Mol Med. 2010 Nov;2(11):440-57.
  • Sanchez P, Ruiz i Altaba A. (2005) In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice. Mechanisms of Development 122, 223-230.